Toxicity in sequential dose-response experiments
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Sequential Analysis
- Vol. 14 (3) , 217-227
- https://doi.org/10.1080/07474949508836333
Abstract
Often, in dose-response studies, it is desirable to arrange treatments in a region defined by the unknown surface. We accomplish such arrangements using sequential designs that are functions of previous outcomes. Here, for a class of randomized up-and-down designs for dichotomous responses (e.g., toxicity/no toxicity) and predetermined sample size, distributional results for the total number of toxic responses are derived. These results are useful in selecting sequential design parameters and have obvious ethical implications.Keywords
This publication has 3 references indexed in Scilit:
- Up-and-down designs. I. Stationary treatment distributionsPublished by Institute of Mathematical Statistics ,1995
- ELEMENTS OF STOCHASTIC PROCESSESPublished by Elsevier ,1975
- A Method for Obtaining and Analyzing Sensitivity DataJournal of the American Statistical Association, 1948