Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma
- 30 November 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (1) , 95-99
- https://doi.org/10.1016/j.febslet.2004.09.092
Abstract
Phenotypic changes in injured livers involve complex network of genes whose interplays may lead to fibrosis and cirrhosis, a major risk of hepatocellular carcinoma. Gene expression profiles in fibrotic livers were analyzed by using cDNA microarray, hierarchical clustering and gene ontology. Analyses of a major cluster of upregulated genes in cirrhosis identified a new set of genes involved in DNA repair and damage. The upregulation of DNA repair genes was confirmed by real-time quantitative polymerase chain reaction and associated with necroinflammatory activity (P<0.001). Increased DNA repair activity in cirrhosis with inflammatory activity may reflect increased DNA damages as a consequence of chronic liver injury.Keywords
This publication has 16 references indexed in Scilit:
- Cancer-associated molecular signature in the tissue samples of patients with cirrhosis†Hepatology, 2004
- Molecular Anatomy of the Human Excision Nuclease Assembled at Sites of DNA DamageMolecular and Cellular Biology, 2002
- Polymorphisms in the DNA repair gene XRCC1 and susceptibility to alcoholic liver cirrhosis in older Southeastern BraziliansCancer Letters, 2002
- Human DNA Repair GenesScience, 2001
- DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesisOncogene, 1999
- Clonal analysis of macronodules in cirrhosisHepatology, 1998
- DNA Structural Elements Required for ERCC1-XPF Endonuclease ActivityJournal of Biological Chemistry, 1998
- An Algorithm for the Grading of Activity in Chronic Hepatitis CHepatology, 1996
- Deficient repair of DNA lesion O6-methylguanine in cirrhosisPublished by Elsevier ,1993
- Incidence and Diagnostic Features of Macroregenerative Nodules Vs. Small Hepatocellular Carcinoma in Cirrhotic LiversHepatology, 1992