Raised Plasma Endothelin During Acute Migraine Attack
- 1 December 1992
- journal article
- Published by SAGE Publications in Cephalalgia
- Vol. 12 (6) , 383-384
- https://doi.org/10.1111/j.1468-2982.1992.00383.x
Abstract
Endothelins are the most potent vasoconstrictor peptides known. Plasma endothelin (ET-1) concentrations were measured in eight migraine patients (mean age 44.5 years), two during an acute migraine attack with aura and six during an attack without aura. The mean ET-1 values were elevated in all migraine patients above the range of normal subjects, and were 10.6 (range 6.0–16.0) pg/ml in migraine patients and 3.8 (range 0.7–5.8) pg/ml in controls. We hypothesize that ET-1 may constrict cerebral vessels during the initial stage of the migraine attack.Keywords
This publication has 8 references indexed in Scilit:
- Raised plasma endothelin-I concentration following cold pressor testPublished by Elsevier ,2004
- Endothelin-1- and endothelin-3-induced vasorelaxation via common generation of endothelium-derived nitric oxideLife Sciences, 1992
- Plasma endothelin during upright tilt: relevance for orthostatic hypotension?The Lancet, 1991
- Endothelins.BMJ, 1990
- RAISED PLASMA ENDOTHELIN IN ANEURYSMAL SUBARACHNOID HAEMORRHAGEThe Lancet, 1989
- Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.Proceedings of the National Academy of Sciences, 1988
- A novel potent vasoconstrictor peptide produced by vascular endothelial cellsNature, 1988
- Ischemia May Be the Primary Cause of the Neurologic Deficits in Classic MigraineArchives of Neurology, 1987