Red Cell Pyrimidine 5′‐Nucleotidase and Glutathione in Myeloproliferative and Lymphoproliferative Disorders

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Abstract
Summary: . Red cell reduced glutatione (GSH) and pyrimidine 5′‐nucleotidase (Pyr 5′‐NT) were measured in a variety of myeloproliferative and lymphoproliferative disorders. Raised levels of GSH were found in chronic lymphocytic leukaemia, Hodgkin's disease, non‐Hodgkin's lymphoma, Waldenstrom's macroglobulinaemia and myeloma. Decreased activity of Pyr 5′‐NT was found in acute myeloblastic leukaemia, acute lymphoblastic leukaemia, chronic granulocytic leukaemia, chronic lymphocytic leukaemia, Hodgkin's disease and non‐Hodgkin's lymphoma. There was no correlation between the raised GSH levels and decreased Pyr 5′‐NT levels.