Proteolytic Digestion Patterns of “Soluble”and “Detergent‐Soluble”Bovine Caudate Nucleus Acetylcholinesterases

Abstract
The structures of purified soluble and detergent-soluble bovine caudate nucleus acetylcholinesterases were compared by peptide mapping on polyacrylamide gels. The digestion products generated from the 2 acetylcholinesterases on proteolysis by a given protease (Staphylococcus aureus V8 protease, .alpha.-chymotrypsin or Papain) are remarkably similar as judged from the electrophoretic band patterns. Evidently, the soluble and detergent-soluble acetylcholinesterases from bovine caudate nucleus share a common evolutionary origin.