Partialsynthesen von Cardenoliden und Cardenolid‐Analogen. VIII. Lactonring‐alkylierte Cardenolide
- 1 January 1983
- journal article
- research article
- Published by Wiley in Journal für Praktische Chemie
- Vol. 325 (4) , 599-606
- https://doi.org/10.1002/prac.19833250409
Abstract
Partial Syntheses of Cardenolides and Cardenolide Analogues. VIII. Lactone Ring‐Alkylated CardenolidesBase‐catalyzed alkylation of digitoxigenin (1), digitoxin (2), digoxigenin (3), and gitoxigenin‐3,16‐diacetate (4) with allyl bromide, allyl chloride or n‐propyl bromide in DMF resulted in the formation of the 22‐allyl‐, 21ξ,22‐diallyl‐, 22‐propyl‐, and 21ξ,22‐dipropyl‐derivatives 5–14, respectively.The determination of the molecular biological activity of the derivatives yielded valuable information.Keywords
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