Modified Macroporous Copolymers of Glycidyl Methacrylate with Ethylene Dimethacrylate as Sorbents for Ion-Exchange and Hydrophobic Interaction Chromatography

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Abstract
Copolymers glycidyl methacrylate-ethylene dimethacrylate which proved to be well suited for size exclusion chromatographic separations in water solutions were provided with hydrophobic alkyl chains containing 4 or 8 carbon atoms or with hydrogen sulfonate groups by simple chemical modifications. Separations of model protein mixtures document the suitability of these sorbents for hydrophobic interaction and ion-exchange chromatography and suggest ways for fine adjustment of the chromatographic conditions assuring the optimal result.