Some Hypothalamic Polyamines That Deplete Pituitary Follicle Stimulating Hormone

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Abstract
Five polyamlne substances already known to occur naturally in mammalian tissues have been isolated from porcine hypothalamic extracts. Taken together, these substances account for most of the FSH-depleting activity of the crude extracts. Of the polyamines iso-lated, histamine is present in the highest amount. However, in the assay method used (decrease of pituitary FSH levels in intact and in castrated testosterone-treated male rats) histamine is active only at [mu]g levels; whereas putrescine, which occurs in smaller amounts, is active down to levels of a few ng. Spermidine, spermine and lysine, which have also been identified, are active at intermediate dose levels. The exact roles of the 5 amines in the turnover of pituitary FSH remain to be elucidated.