Antiinflammatory effects of some copper complexes

Publisher Website
Google Scholar
Abstract
Cu complexes of a range of ligands were prepared and evaluated for antiinflammatory activity and irritancy after oral, s.c. and local administration in rats and guinea pigs. The antiinflammatory activities depended on the species used and the route of administration. When nonantiinflammatory ligands were used, the response was generally dose dependent. With D-penicillamine and when the ligands were themselves antiinflammatory in animal models of inflammation, as with flufenamic acid, levamisole, aspirin, L-histidine and 2-amino-2-thiazoline, differences in antiinflammatory activity were observed between the Cu complexes and the free ligands. In some cases, the Cu complexes were the more effective. There was a weak correlation between local (subplantar) irritation and the dose of Cu but, for 4 compounds studied in more detail, the response in the local subplantar test and degree of antiinflammatory activity were not related, suggesting that the action of Cu is not solely by a counterirritant mechanism. No obvious differences between the activity of Cu(I) and Cu(II) compounds were observed, suggesting that a common metabolite may be involved in the antiinflammatory action of Cu.