Chronic neuropathy with IgM anti-ganglioside antibodies: Lack of long term response to rituximab
- 23 December 2003
- journal article
- case report
- Published by Wolters Kluwer Health in Neurology
- Vol. 61 (12) , 1814-1816
- https://doi.org/10.1212/01.wnl.0000098996.02934.86
Abstract
Two patients with chronic motor neuropathy, high antiganglioside antibody (AGA) titers, and a declining response to IV immunoglobulins were treated with rituximab at a standard dose. The drug was well tolerated and effectively eliminated peripheral B cells (CD20+), but AGA titers continued significantly high. No clinical improvement was detected during the 1-year follow-up.Keywords
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