Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
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- 1 March 2001
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 7 (3) , 297-303
- https://doi.org/10.1038/85438
Abstract
The initiation of T-cell–mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell–dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions.Keywords
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