Characterization of FcεRIγ in human natural killer cells
- 1 August 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 4 (8) , 955-958
- https://doi.org/10.1093/intimm/4.8.955
Abstract
We report the characterization of the FcεRIγ chain which associates with the transmembrane form of CD16 to form the low affinity receptor for IgG (FcγRIII) expressed on human natural killer (NK) cells. cDNA cloning and sequence analysis of FcεRlγ from a polyclonal CD3−CD16+ NK line established that this molecule is identical to FcεRlγ previously identified in human basophiis as part of a high affinity receptor for IgE. Polymerase chain reaction analysis of FcεRIγ gene expression in a series of CD3+CD16− and CD3−CD16+ NK clones reveals that FcεRIγ is not directly linked to NK activity since clones of the CD3+CD16− phenotype lack FcεRIγ RNA but nevertheless mediate cytotoxlclty. Taken together, these results demonstrate that the FcεRIγ molecule is expressed in various types within the hematopoietic system as part of muitimeric surface receptors involved in different biological functions.Keywords
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