Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage

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Abstract
Phenytoin sodium i.v. in small volumes of normal saline was administered for treatment of convulsions in 200 patients. A total of 72 complications developed in 51 patients. Twenty-nine complications were burning pain at the i.v. site, and 36 were related to excessive total dose of phenytoin and resultant drug intoxication. Seven other patients had cardiovascular complications, including hypotension and arrhythmias. These 7 complications were related to high concentrations of drug administered at a rapid rate. Both the i.v. and cardiovascular complications promptly resolved when the i.v. rate was slowed or temporarily stopped. No patient died and none was hospitalized because of a complication.