Injection vs. Oral Administration of Folic Acid in the Chick
- 22 November 1946
- journal article
- letter
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 104 (2708) , 492-493
- https://doi.org/10.1126/science.104.2708.492-a
Abstract
Synthetic folic acid, 200 [gamma]/ml., was dissolved with a trace of NH40H at pH 7. Benzyl alcohol, 1.5%, was added, and the soln. was sterilized by filtration. The potency of the soln. was standardized by microbiol. assay with Lactobacillus casei. Day-old Black Leghorn chicks on a basal diet were divided into 6 groups of 8 each. Three groups were given dilution aliquots of the folic acid soln. orally in amts. of 5, 10, and 20 [gamma]/day. The folic acid was about twice as effective when given to the other 3 groups in similar dilutions by intramusc. injn. at levels of 2.5, 5, and 10 [gamma]/day. There was also a higher survival in the injected animals.This publication has 1 reference indexed in Scilit:
- Adequacy of the Known Synthetic Vitamins for Normal Feathering and Pigmentation in ChicksExperimental Biology and Medicine, 1946