The insulin‐like growth factor‐I/binding protein axis: physiology, pathophysiology and therapeutic manipulation
Open Access
- 1 September 1993
- journal article
- review article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 23 (9) , 503-516
- https://doi.org/10.1111/j.1365-2362.1993.tb00958.x
Abstract
Insulin-like growth factor-I (IGF-I) is a single-chain polypeptide which has multiple metabolic actions and effects on the differentiation and proliferation of a wide variety of cell types. IGF-I has endocrine, paracrine and autocrine actions and is bound in the circulation to a complex system of binding proteins which alter its bioavailability and activity. Thus its physiology is complex and is altered in a number of pathological states. This review will discuss these states and the actual and proposed therapeutic applications of recombinant human IGF-I (rhIGF-I).Keywords
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