Removal of HLA-A,B antigens from platelets
Open Access
- 1 February 1984
- journal article
- Published by American Society of Hematology in Blood
- Vol. 63 (2) , 448-450
- https://doi.org/10.1182/blood.v63.2.448.448
Abstract
Recent evidence suggests that HLA-A,B antigens present on human platelets, are acquired from plasma. Using hypertonic acid chloroquine (200 mg/ml, pH 5.0, 1 hr, 4 degrees C), we demonstrate elution of most or all HLA-A2 and HLA-B7,40 immunoreactive material from platelets. Corresponding antigens on human lymphocytes were not affected by this treatment. These findings are consistent with the hypothesis that HLA- A,B antigens are adsorbed onto platelet surfaces.Keywords
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