Cleft palate: players, pathways, and pursuits
Open Access
- 15 June 2004
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 113 (12) , 1676-1678
- https://doi.org/10.1172/jci200422154
Abstract
Cleft lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models. Mouse models in particular have made a substantial contribution to our understanding of the gene pathways involved in palate development and the nature of signaling molecules that act in a tissue-specific manner at critical stages of embryogenesis. Related work has provided further support for investigating the role of common environmental triggers as causal covariates.Keywords
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