Solid Base-directed Regioselective Ring Opening of Epoxides with Cyanotrimethylsilane
- 1 March 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 19 (3) , 481-484
- https://doi.org/10.1246/cl.1990.481
Abstract
Calcium oxide and magnesium oxide are found to be effective solid bases for nucleophilic ring opening of epoxides with cyanotrimethylsilane to afford β-trimethylsiloxy nitriles in a highly regioselective manner without any contamination of isocyanides.Keywords
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