Psychosocial Disability During the Long-term Course of Unipolar Major Depressive Disorder

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Abstract
RECENT STUDIES indicate that unipolar major depressive disorder (MDD) is associated with significant psychosocial disability, often exceeding that noted in common medical illnesses.1-9 A definitive monograph in 1996 by the World Health Organization identified unipolar MDD as the fourth-ranked cause of disability-adjusted life-years and premature death worldwide.10