An immunospecific microbalance
- 1 November 1972
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 6 (6) , 565-570
- https://doi.org/10.1002/jbm.820060608
Abstract
A piezoelectric quartz crystal microbalance has been modified for the determination of antibody activity in solution. Antigen precoated crystals are exposed to antisera of varying concentration and specificity. Only antisera specific for the antigen precoat will form an additional protein layer on the crystal. The thickness of the antibody layer, measured by thefrequency shift of the crystal, is proportional to the concentration of specific antibody in solution. The technique provides a rapid qualitative and quantitative assay of antibody activity.Keywords
This publication has 3 references indexed in Scilit:
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- Adsorption of Proteins by Polystyrene ParticlesThe Journal of Immunology, 1967
- On the average hydrophobicity of proteins and the relation between it and protein structureJournal of Theoretical Biology, 1967