Pyoderma gangrenosum and myeloproliferative disorders. Report of a case and review of the literature

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Abstract
The exact mechanism involved in the pathogenesis of pyoderma gangrenosum (PG) still remains unclear, yet there is an increasing number of reports associating PG with immunologic abnormalities. A correlation between PG and myeloproliferative disorders was also described. A patient with chronic myelocytic leukemia is described in whom PG developed during the course of illness. An immunologic analysis of this case, speculation on the pathogenesis of PG and a review of the literature are presented. The futility of current therapeutic modalities in the treatment of PG is reported.

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