PREDICTION OF HUMAN-TUMOR CELL CHEMOSENSITIVITY USING THE SISTER CHROMATID EXCHANGE ASSAY
- 1 April 1986
- journal article
- research article
- Vol. 46 (4) , 1599-1602
Abstract
The sister chromatid exchange (SCE) assay has been used to predict the chemosensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea of various neoplastic cell subpopulations in eight cell lines derived from human brain tumors. Because the SCE assay is based on analysis of individual cells, data obtained can be plotted as frequency histograms of SCEs per chromosome, and the range of chemosensitivities of cell subpopulations can be identified easily. Results suggest that the SCE assay has predictive value as a clinical assay for drugs for which a strong correlation between cell kill and induction of SCEs has been established.This publication has 8 references indexed in Scilit:
- Potentiation of 1,3-BIS(2-chloroethyl)-1-nitrosourea (BCNU)-induced cytotoxicity in 9L cells by pretreatment with 6-thioguanineBiochemical Pharmacology, 1985
- Effect of Cell-Cell Interactions on Drug Sensitivity and Growth of Drug-Sensitive and -Resistant Tumor Cells in SpheroidsScience, 1984
- Detection of heterogeneity in the chemosensitivity of 9L brain tumor cell lines to 1,3-bis (2-chloroethyl)-1-nitrosourea by the sister chromatid exchange assayEuropean Journal of Cancer and Clinical Oncology, 1984
- BCNU-Induced Sister Chromatid Exchanges Are Increased by X IrradiationRadiation Research, 1984
- NITROSOUREA-INDUCED SISTER CHROMATID EXCHANGES AND CORRELATION TO CELL-SURVIVAL IN 9L RAT-BRAIN TUMOR-CELLS1983
- Polyamine Depletion Influences Drug-Induced Chromosomal DamageScience, 1982
- Development of a clonogenic cell assay for human brain tumorsCancer, 1978
- Primary Bioassay of Human Tumor Stem CellsScience, 1977