PREDRUG BEHAVIOR AS A PREDICTOR OF RESPONSE TO PHENOTHIAZINES AMONG SCHIZOPHRENICS

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Abstract
Data from a large-scale cooperative trial of five phenothiazines and phenobarbital with schizophrenic patients were analyzed to determine what predrug patterns of behavior predicted responsiveness to the individual drugs. Individual responsiveness to the four drugs which showed the greatest effectiveness, chlorpromazine, triflupromazine, perphenazine and prochlorperazine, was computed using a score which allowed for individual differences in initial scores and which made for comparability between the four drug groups. These responsiveness scores were then correlated with Multidimensional Rating Scale scores made on the study subjects before drug administration started. Responsiveness to chlorpromazine is associated with cooperativeness, response to perphenazine with sociability, response to prochlorperazine with activity level and response to triflupromazine with anxiety and tension. A comparison with the data from the Spring Grove comparative phenothiazine study suggests that most of these correlations are stable.

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