Inhibitory Effect of Ammonium Sulfate on Columbia SK Virus Propagation in Mouse Ascites Tumor Cells in vitro.

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Abstract
An inhibitory effect of ammonium sulfate on Col SK virus propagation in in vitro cultures of mouse ascites tumor cells has been described. The effect was observed on virus synthesis, HA production, and CPE. Single cycle virus growth experiments showed that ammonium sulfate was apparently effective even at the later stage of the latent period. The effect was limited to the HA-positive strain of Col SK virus; the HA-negative strain of Col SK virus and a neurotropic virus (LCM, strain NY#621) were completely resistant to the ammonium ion in the same system.