ALPHA-1 BLOCKERS. A NEW GENERATION OF ANTIHYPERTENSIVE AGENTS
Open Access
- 1 August 1989
- journal article
- review article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 14 (4) , 263-283
- https://doi.org/10.1111/j.1365-2710.1989.tb00248.x
Abstract
Alpha-1 blockers have certain disadvantages over conventional and antihypertensive therapies in their haemodynamic profile and metabolic effects. This paper reviews the development of alpha-blockade, the therapeutic efficacy of prazosin, the prototype alpha-1 blocker, and the rationale for the once-daily antihypertensive compounds, terazosin and doxazosin. These drugs offer a useful alternative to first- or second-line therapy in suitable hypertensive patients, particularly with their potentially beneficial effects on serum lipids.Keywords
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