Comparative in vitro Activity of 11 ß‐lactam Antibiotics against 91 Staphylococcus intermedius Strains isolated from Staphylococcal Dermatitis in Dogs

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Abstract
Summary: A study was made of the susceptibility of 91 strains of Staphylococcus intermedius, isolated from staphylococcal dermatitis of dogs, to 11 ß‐lactam antimicrobial agents. The activity of these antimicrobial agents against all strains was tested at pH 7.2 and 8.5. Finally, a comparative study was made of the susceptibility of these micro‐organisms, dividing them into six groups: ß‐lactamase positive and negative, methicillin resistant and susceptible and oxacillin resistant and susceptible. Only three of the 11 antimicrobial agents studied exhibited satisfactory behaviour at the two pH levels studied: mezlocillin, cefazolin and cefalotine. There was a good correlation at pH 8.5 between methicillin‐resistant strains and those resistant to penicillin G, ampicillin, amoxycillin, cefamandole and cefuroxime. This correlation was not observed, however, between oxacillin‐resistant strains and strains resistant to the other antimicrobial agents studied.