Alzheimer's Disease and Apolipoprotein E in Italya
- 1 January 1996
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 777 (1) , 260-265
- https://doi.org/10.1111/j.1749-6632.1996.tb34429.x
Abstract
Recent studies have provided evidence of association of apolipoprotein E (ApoE) ε4 allele and late onset familial and sporadic Alzheimer's disease (AD). Epidemiological studies have established allelic variation at the ApoE locus. We have analyzed the ApoE gene polymorphism in a sample of 416 Italian subjects. Our data confirm a significant association between ε4 allele and sporadic AD. The frequency of ε4 allele in early onset familial AD patients was comparable to control values suggesting that ε4 allele does not represent a risk factor for early onset familial AD (EOFAD). Moreover, we found a not‐previously reported association between ApoE ε2 allele and sporadic AD and EOFAD. We included in this study two EOFAD families with the APP717 Val → Ile mutation in the Amyloid Precursor Protein (APP) gene on chromosome 21.In any of the EOFAD families there was a significant effect of the ApoE genotype on the age of onset with the exception of one of the two mutated EOFAD families in which the 2 allele delays the age of onset.Keywords
This publication has 13 references indexed in Scilit:
- The apolipoprotein E ε4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutationsAnnals of Neurology, 1994
- Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer diseaseNature Genetics, 1994
- APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's diseaseNeuroscience Letters, 1994
- Alzheimer's Disease and Possible Gene InteractionScience, 1994
- Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.Proceedings of the National Academy of Sciences, 1993
- Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's diseaseNeurology, 1993
- APP717 and Alzheimer's disease in ItalyNature Genetics, 1993
- Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14Nature Genetics, 1992
- Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob diseaseBrain Research, 1991
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991