Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma
Open Access
- 1 May 2001
- journal article
- Published by Elsevier
- Vol. 276 (21) , 18497-18506
- https://doi.org/10.1074/jbc.m100638200
Abstract
No abstract availableKeywords
This publication has 47 references indexed in Scilit:
- Human p53 Is Phosphorylated on Serines 6 and 9 in Response to DNA Damage-inducing AgentsJournal of Biological Chemistry, 2000
- Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligaseOncogene, 2000
- Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53Journal of Biological Chemistry, 2000
- Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin BOncogene, 1999
- Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53The EMBO Journal, 1999
- DNA damage activates p53 through a phosphorylation–acetylation cascadeGenes & Development, 1998
- Differences in epitope accessibility of p53 monoclonal antibodies suggest at least three conformations or states of protein binding of p53 protein in human tumor cell linesCell Death & Differentiation, 1998
- The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylateOncogene, 1997
- Regulation of p53 stability by Mdm2Nature, 1997
- Elevated levels of wild-type p53 induced by radiolabeling of cells leads to apoptosis or sustained growth arrestCurrent Biology, 1995