p53 and PUMA: A Deadly Duo
- 9 September 2005
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5741) , 1685-1686
- https://doi.org/10.1126/science.1118232
Abstract
The p53 tumor suppressor protein exhibits a number of activities that contribute to the induction of apoptosis. In her Perspective, Vousden discusses a study by Chipak et al. That describes how the nuclear and cytoplasmic functions of p53 can be elegantly brought together into the same pathway. This explains why both might be needed for the efficient induction of cell death.Keywords
This publication has 15 references indexed in Scilit:
- PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53Science, 2005
- Stress-induced p53 runs a transcription-independent death programBiochemical and Biophysical Research Communications, 2005
- Complicating the complexity of p53Carcinogenesis: Integrative Cancer Research, 2005
- Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic FunctionMolecular Cell, 2005
- BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and IndirectlyMolecular Cell, 2005
- Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complexNature Cell Biology, 2004
- Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and ApoptosisScience, 2004
- No PUMA, no deathCancer Cell, 2003
- Gene expression during ER stress–induced apoptosis in neuronsThe Journal of cell biology, 2003
- Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsCancer Cell, 2002