The frequency in Japanese of genetic variants of 22 proteins I. Albumin, Ceruloplasmin, Haptoglobin, and Transferrin

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Abstract
An electrophoretic survey of approximately 4000 individuals from the cities of Hiroshima and Nagasaki, Japan was taken of 4 serum proteins: albumin, ceruloplasmin, haptoglobin and transferrin. The haptoglobin gene frequencies obtained for the HP1-HP2 polymorphism are in agreement with earlier reports. Rare electrophoretic variants of albumin, ceruloplasmin and haptoglobin occur with frequencies of 2.48, 0.50 and 0.58/1000 determinations, respectively. The noteworthy finding of 8 distinct transferrin variants in these populations, with a combined frequency of 20.90/1000 determinations, is presented. Four of these variants (DChi, B1, B3 and DHIR 2, which corresponds electrophoretically to D4) were reported in other populations in Japan, but the other 5 have not been previously differentiated.