No TP53 mutations in neuroblastomas detected by PCR‐SSCP analysis
- 1 June 1994
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 10 (2) , 136-138
- https://doi.org/10.1002/gcc.2870100209
Abstract
We have analysed 29 neuroblastomas for TP53 mutations in exons 5 to 8 by means of the polymerase chain reaction in combination with the single‐strand conformation polymorphism technique. We could not detect any mutation. These results indicate that, in contrast to the majority of tumors so far studied, TP53 mutations do not seem to be important for the development of neuroblastomas. Genes Chromosom Cancer 10:136–139 (1994).Keywords
This publication has 9 references indexed in Scilit:
- Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanomaInternational Journal of Cancer, 1993
- Neurofibromatosis type 1 gene mutations in neuroblastomaNature Genetics, 1993
- Loss of heterozygosity for distal markers on 22q in human gliomasInternational Journal of Cancer, 1992
- p53 Mutations in Human CancersScience, 1991
- Transcription of N-myc and proliferation-related genes is linked in human neuroblastomaCancer Letters, 1991
- Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reactionGenomics, 1989
- Prognostic factors in neuroblastomaCancer, 1987
- Overproduction of p53 antigen makes established cells highly tumorigenicNature, 1985
- Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease StageScience, 1984