A 195Pt and 15N N.M.R. study of the anticancer drug, cis-diammine-dichloroplatinum(II), and its hydrolysis and oligomerization products

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Abstract
195Pt and 15N n.m.r, spectra for aqueous solutions of the anti-cancer drug cis-diamminedichloroplatinum(II) and its hydrolysis and oligomerization products are reported. In the blood substituteHanks medium, conversion of cis-[Pt(15NH3)2(H20)2](NO3)2 into cis[PtCl2(15NH3)2], cis-[PtCl(H20)(15NH3)2]+,[Pt(15NH3)2OH]33+ and [Pt(15NH3)2OH]22+ has been observed, the reaction taking several hours at 30ºC. In 0.15 M sodium chloride, both [Pt(NH3)2OH]33+ and[Pt(NH3)2OH]22+ are converted overnight into cis-[PtCl(H2O)(NH3)2]+. The infrared bands at 546 and 522 cm-1 in [Pt(NH3)2OH]2SO4 and at 520 cm-1 in [Pt(NH3)2OH]2(SO4)3 have been reassigned to Pt-N modes.