Studies on Antiulcer Drugs. II. Synthesis and Antiulcer Activities of Imidazo(1,2-a)pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-Tetrahydroimidazo(1,2-a)pyridinyl Derivatives.
- 1 January 1992
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 40 (2) , 371-380
- https://doi.org/10.1248/cpb.40.371
Abstract
A series of imidazo[1, 2-a]pyridinylbenzoxazoles (4) and 5, 6, 7, 8-tetrahydroimidazo[1, 2-a]pyridinylbenzoxazoles (5) were synthesized and tested for anti-stress ulcer activity in rats. Several compounds were found to be more active than the reference compounds, sucralfate, cimetidine and ranitidine. Some of them exhibited potent protective activity against ethanol-induced gastric lesion. The synthesis and structure-activity relationships of these compounds are discussed.Keywords
This publication has 0 references indexed in Scilit: