Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans
- 1 November 2009
- journal article
- Published by American Society for Microbiology in Eukaryotic Cell
- Vol. 8 (11) , 1803-1807
- https://doi.org/10.1128/ec.00240-09
Abstract
Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.Keywords
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