Identification of antigenically related polypeptides at centrioles and basal bodies.

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Abstract
An antigen localized at the centriolar region was identified by indirect immunofluorescence studies in African green monkey kidney, human, hamster, rat and mouse cells. The antigen consists of 2 polypeptides of 14,000 and 17,000 daltons. A related antigen is also present at the basal body region in ciliated cells from chicken, cat, mouse, pig, steer and rabbit trachea and from rabbit fimbria. Immunoelectron microscopy shows that the immunoreactive antigen is located in the region around the basal bodies of ciliated cat tracheal cells. Thus, an antigen that is common to a variety of cell types from many different animal sources and is specifically associated with centrioles and basal bodies was found. The possible role of the antigen in differentiation is discussed.