Genetic determinants for infectivity and pathogenicity of influenza viruses
Open Access
- 25 February 1980
- journal article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 288 (1029) , 393-399
- https://doi.org/10.1098/rstb.1980.0016
Abstract
The objective of the studies presented was to define a molecular basis for infectivity and pathogenicity of influenza virus. It is demonstrated that activation of the HA glycoprotein by post-translational proteolytic cleavage is indispensable for the formation of infectious influenza virus.Keywords
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