EFFECT OF N-CARBOXYMETHYL-N-NITROSOUREA ON VIABILITY AND MUTAGENIC RESPONSE OF REPAIR-DEFICIENT STRAINS OF ESCHERICHIA-COLI
- 1 January 1979
- journal article
- research article
- Vol. 70 (5) , 705-708
Abstract
Under simulated human gastric conditions, glycocyamine which exists in meat is converted into N-carboxymethyl-N-nitrosourea (CMNU) by reaction with sodium nitrite. Because of its suspected hazards to man [including possible carcinogenicity], CMNU was tested for its mutagenicity and lethal activity with a set of isogenic strains of E. coli possessing the same auxotrophic marker but different DNA-repair capacities. Strains NG30 (recA-) and R15 (polA-) were far more sensitive to lethality induced by CMNU than H/r30R (wild) and Hs30R (uvrA-) strains. The uvrA- strain was more sensitive to induction of mutations by CMNU than the wild and polA- strains, but the recA- strain was hardly mutable by CMNU. The major cause of lethality of CMNU in E. coli apparently is different from that of mutation induction.This publication has 3 references indexed in Scilit:
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