Generation of Non-Complement-Fixing, Blocking Factors by Lysosomal Extract Treatment of Cytotoxic Anti-Tumor Antibodies
Open Access
- 1 September 1974
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 113 (3) , 948-953
- https://doi.org/10.4049/jimmunol.113.3.948
Abstract
Alloantibodies against EL-4 lymphoma and P-815 mastocytoma were raised by immunization of DBA/2 and C57BL/6 mice, respectively. Such antisera were capable of mediating complement-dependent cytotoxicity and of blocking specific killing by alloimmune lymphocytes. Treatment with lysosomal enzymes derived from the tumor decreased the ability of these alloantibodies to mediate complement-dependent cytotoxicity but left intact their blocking activity. Such degradation, if it were to occur, in vivo could contribute to enhanced tumor growth.Keywords
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