Modulation of Human Gastric Mucosal Adenylate Cyclase Activity by Prostacyclin
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 19 (2) , 137-139
- https://doi.org/10.1159/000198335
Abstract
Prostacyclin, its stable metabolite 6-keto-prostaglandin F1αand prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1α (each 0.28 mM) increased the enzyme activity 3.0 and 1.6 fold, respectively. The concentrations of prostacyclin and prostaglandin E2 required to produce half maximal activation were in the same range. Prostacyclin is an efficient stimulator of human gastric mucosal adenylate cyclase.This publication has 5 references indexed in Scilit:
- Activation of human adenylate cyclase in the upper gastrointestinal tract by vasoactive intestinal polypeptideGastroenterology, 1978
- Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acidProstaglandins, 1977
- HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATIONThe Lancet, 1977
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951