Total free radical trapping antioxidant potential in pre‐eclampsia

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Abstract
Objective: The aim of the present study was to measure serum urate, tocopherol and ascorbate and to calculate total radical trapping antioxidant potential (TRAP) in pre‐eclampsia. Methods: Study samples were taken from 25 pre‐eclamptic, 25 normotensive pregnant and 25 non‐pregnant healthy females for measuring uric acid, vitamin C and E, total sulfhydryl group. Also lipid peroxidation product malonaldehyde (MDA), the superoxide generation (NBT reduction) were estimated and TRAP was calculated. Data were analyzed statistically using Student's t‐test. Result: Pre‐eclamptic women had significantly increased MDA levels, superoxide generation and uric acid levels as compared to control subjects (PPConclusion: TRAP provides a means of assessing the total capacity of the chain‐breaking antioxidants to prevent lipid peroxidation in plasma.