Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.
- 1 July 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (13) , 5183-5187
- https://doi.org/10.1073/pnas.86.13.5183
Abstract
We have investigated the role of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, in the responses of cells in adult cat visual cortex. After intracortical infusion of the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate (DL-APV) for one day, iontophoretic responses to NMDA, to kainate, and to quisqualate revealed a receptor blockade specific to NMDA receptors and extending several millimeters from the cannula. In this region, neuronal responses to visual stimulation were profoundly suppressed, in a manner strongly correlated with the degree of NMDA receptor blockade. Neither NMDA receptor blockade nor activity suppression was caused by the inactive stereoisomer L-APV. Hence, we conclude that NMDA receptors make a major contribution to normal excitatory transmission in adult visual cortex.This publication has 29 references indexed in Scilit:
- Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate CortexScience, 1987
- NMDA receptors in the visual cortex of young kittens are more effective than those of adult catsNature, 1987
- The physiology of excitatory amino acids in the vertebrate central nervous systemProgress in Neurobiology, 1987
- Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanismNature, 1986
- Mediation of thalamic sensory input by both NMDA receptors and non-NMDA receptorsNature, 1986
- A synaptic potential following single volleys in the hippocampal CA1 region possibly involved in the induction of long‐lasting potentiationActa Physiologica Scandinavica, 1985
- Structure-activity relations of dipeptide antagonists of excitatory amino acidsNeuroscience, 1984
- Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cordBrain Research, 1982
- Anatomical organization of the primary visual cortex (area 17) of the cat. A comparison with area 17 of the macaque monkeyJournal of Comparative Neurology, 1979
- Tungsten Microelectrode for Recording from Single UnitsScience, 1957