Neuron-Glia Adhesion Is Inhibited by Antibodies to Neural Determinants
- 7 October 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4619) , 60-62
- https://doi.org/10.1126/science.6194561
Abstract
Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.Keywords
This publication has 20 references indexed in Scilit:
- Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture.The Journal of cell biology, 1983
- Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitroNature, 1982
- Kinetic and morphological analysis of the preferential adhesion of chick embryo neuronal cells to astroglial cells in cultureExperimental Cell Research, 1982
- Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture.The Journal of cell biology, 1980
- Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retinaeNature, 1980
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Surface Components and Cell RecognitionAnnual Review of Biochemistry, 1979
- Adhesion among neural cells of the chick embryo. III. Relationship of the surface molecule CAM to cell adhesion and the development of histotypic patterns.The Journal of cell biology, 1978
- Preparation of pure neuronal and non-neuronal cultures from embryonic chick sympathetic ganglia: A new method based on both differential cell adhesiveness and the formation of homotypic neuronal aggregatesBrain Research, 1976
- Behaviour of neuroblasts in the presence of glial cells, fibroblasts and meningeal cells in cultureExperimental Cell Research, 1974