Capture du paradiméthoxyorthoquinodiméthane: synthèses de quinones et d'un intermédiaire de la daunomycinone
- 15 June 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 58 (12) , 1161-1167
- https://doi.org/10.1139/v80-181
Abstract
New para-dimethoxyl and para-diacetoxy derivatives in the naphthalene, anthracene, naphthacene, naphtho (2,3-c) thiophene and benzo-c thiophene series are synthesized via the trapping of o-quinodimethanes by various dienophiles. Among these compounds, an intermediate for the synthesis of daunomycinone has been prepared and can be oxidized to a benzoquinone which provides access to new analogues of this important antileukemic agent. [Journal translation]This publication has 1 reference indexed in Scilit:
- Synthetic routes to (±)-daunomycinone: elaboration of the hydroxy-ketone group from an α-tetralone derivative, and selective methylation of the C(4)-hydroxy group using diazomethaneJournal of the Chemical Society, Chemical Communications, 1979