Inhibition of Cold-Promoted Activation of the Prothrombin Time Studies of New Siliconized Borosilicate Collection Tubes in Normals and Patients Receiving Warfarin
Open Access
- 1 April 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 83 (4) , 492-494
- https://doi.org/10.1093/ajcp/83.4.492
Abstract
Studies of the prothrombin time in normals and patients receiving oral anticoagulant therapy revealed a partial inhibition of the in vitro cold-promoted activation of Factor VII and shortening of the prothromobin time when blood was collected in a new commercial siliconized borosilicate tube (Becton–Dickinson, Rutherford, NJ, 6418 and 6419). The data collected with normal blood indicated that the cold-promoted activation was almost totally inhibited, while the patients had only a mean reduction of 50% of the cold-promoted activation. In pregnant patients there was no inhibition of the cold-promoted activation of the prothrombin time or Factor VII using the new siliconized tubes.Keywords
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