Acute Hepatitis With Bridging Necrosis due to Hydralazine Intake
- 1 June 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 139 (6) , 698-699
- https://doi.org/10.1001/archinte.1979.03630430074024
Abstract
A 59-year-old woman was admitted to the hospital for evaluation of her hypertension. She was treated with hydralazine; two days later a severe acute hepatitis supervened. On discontinuation of the agent, the liver damage disappeared, relapsed during inadvertent rechallenge, and healed following permanent withdrawal from the drug. Histologic study of the liver showed severe acute hepatitis with bridging necrosis (so-called subacute hepatitis). Six months after discontinuation of hydralazine, a second liver biopsy specimen showed a complete remission of the disease. This hydralazine-induced hepatitis appears to be fully reversible and to differ both on clinical and histological grounds from two previous reports documenting a granulomatous liver disease. (Arch Intern Med139:698-699, 1979)This publication has 2 references indexed in Scilit:
- Aspirin-Induced Hepatotoxicity in Patients with Systemic Lupus ErythematosusAnnals of Internal Medicine, 1974
- Drug-induced active chronic hepatitisDigestive Diseases and Sciences, 1973