Polyunsaturated Fatty Acids in Hyperlipoproteinemia

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Abstract
The daily oral administration of 2 mM (1,700 mg) lecithin linoleate, as Lipostabil®, to five males with hypertriglyceridemia, caused after 5 weeks a mean increase (p < 0.05) of α-lipoproteins (measured as cholesterol content), a mean increase in relative linoleic acid (18:2) content of α-lipoprotein phosphoglycerides and a tendency to serum triglyceride reduction (by 16 %). Linoleic acid containing α-lipoprotein phosphoglycerides (estimated on absolute amounts) were inversely related (r = -0.68; p < 0.001) to log serum triglyceride values. It is suggested that one beneficial effect of linoleic acid (and lecithin linoleate) in hypertriglyceridemia might be mediated through an increase in α-lipoproteins and specifically in α-lipoprotein lecithin linoleic acid, i.e. a substrate in the lecithin:cholesterol acyl transferase (LCAT) reaction.

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