Design requirements for pyroglutamic acid substitutions in peptides
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 3363-3365
- https://doi.org/10.1039/p19900003363
Abstract
Conformational energy calculations and geometrical arguments indicate that L-pyroglutamic acid (Glp) is an unusual amino acid residue in that its backbone conformational requirements are similar to those normally associated with a standard D-amino acid residue.Keywords
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