Ophthalmoscopic Observasions of Ocular Fundus in Colony-born Cynomolgus Monkeys Aged from 0 day to 90 days

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Abstract
Apparently, healthy colony-born cynomolgus monkeys (M. fascicularis) (242) from 0-90 days old were examined; the findings of the ocular fundus by ophthalmoscope were recorded. One drop of solution of 0.5% tropicamide and 0.5% phenylephrine hydrochloride was instilled into each eye of the monkey. Then, those monkeys were anesthetized with ketamine hydrochloride at the dose level of 10 mg/kg. Regular and fluorescein photographs were taken using daylight color film. Retinal color was salmon pink with 0 to 3-day-old neonates, salmon pink and blue to green with 7 days to 14-day-old animals and blue to green with 60-days to 90-days-old monkeys. As regards the optic disc, 0- to 14-day-old animals were light orange in color, and infants aged more than 28-days showed orange color. Retinal arteries and veins were lightly reddish in color with every age class. Macular color was salmon pink in 0-day-old cases, slightly dark in 3-days-old neonates and very dark after 14-days of age. Lightly retinal reflex was noted in 0- and 7-day-old animals. The reflex was observable in 14-day-old animals without exception. Retinal hemorrhages were recorded in 22 (67%) of 36 neonates born in natural condition and 10 (33%) of 30 neonates born by cesarean section. These findings will be useful as the criteria for ophthalmoscopic observations of the cynomolgus monkeys in labortory use.

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