Dose-Response Relationship in Aminonucleoside Nephrosis.

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Abstract
The induction and severity of aminonucleoside (9-(3[image]-amino-3[image]-deoxy-B-D-ribofuranosyl)-6-dimethyl aminopurine) (PA) induced nephrosis in rats was studied by varying the dose, frequency of injection, and route of administration. The minimum total dose required to produce proteinuria in 200 g rats was 4-5 mg. Administration of 1-2 mg subcutaneously at biweekly intervals enhanced the effectiveness of the drug although the induction period was prolonged. Administration of 3 mg per 200 g rat for 2-4 days resulted not only in acute severe proteinuria but also in chronic proteinuria of a milder degree lasting several months. These findings do not support the idea that PA acts by direct enzyme inhibition.

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