DETERMINATION OF C-REACTIVE PROTEIN IN THE BLOOD OF PATIENTS WITH HODGKIN'S DISEASE

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Abstract
A study of 121 Hodgkin''s patients showed that a change in Hodgkin s paragranuloma to a disseminated form of Hodgkin''s disease is mirrored in the appearance of C-reactive protein in the blood. Following early, aggressive treatment of localized Hodgkin''s granuloma, C-reactive protein disappears from the blood. With recrudescence of disease activity, the C-reactive protein reappears and, with generalization of the disease, persists. C-reactive protein does not provide an accurate, sensitive measure of response to therapeutic agents in patients with generalized Hodgkin''s disease for there is no consistent effect on the protein by the various therapeutic agents, despite clinical improvement.